"RNA: Versatility in Form and Function".
Mark G. Caprara and Timothy W. Nilsen
Center for RNA Molecular Biology, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
Correspondence should be addressed to: M G Caprara, e-mail: mgc3@po.cwru.edu
and T W Nilsen, e-mail: twn@po.cwru.edu
Abstract:
RNA performs a remarkable range of functions in all cells. In addition
to its central role in information transfer from DNA to protein, it is
essential for functions as diverse as RNA processing, chromosome end-maintenance
and dosage compensation. The versatility of RNA derives from its unique
ability to use direct readout via base-pairing for sequence specific
targeting (or templating) in combination with its capacity to form elaborate
three dimensional structures. Such structures can perform catalysis or
serve as protein recognition surfaces. In this short review, we attempt
to give a flavor for the diversity of functional RNAs in the cell and highlight,
using selected examples, two quite distinct activities, catalysis and sequence
specific targeting. Within each section, we discuss how the lessons we
have learned from these systems may apply to other, less well understood,
RNAs.
Additional References:
1. "Nuclear Polyanions as De-Repressors of Synthesis of Ribonucleic Acid".
2. "Mated Models of Gene Regulation in Eukaryotes".
3. "Selective Gene De-Repression by De-Repressor RNA".
4. "Oncogenes as Molecular Targets within
Active Chromatin".