Published in: Proc. Natl. Acad. Sci. USA, vol. 52, pp. 915-922 (1964):

"Identity of DNA and Diversity of Messenger RNA Molecules in Normal Mouse Tissues".

B. J. McCarthy* and B. H. Hoyer

Department of Terrestrial Magnetism, Carnegie Institution of Washington,  and Laboratory of Biology of Viruses, National Institutes of Health, Bethesda, MD, USA

* Present Address:  Department of Microbiology, School of Medicine, University of Washington, Seattle, WA, USA


Summary:

The formation of duplex structures by DNA or RNA with DNA entrapped in agar has been used as a means of assessing similarities and differences among the populations of nucleic acids in various tissues of the mouse. Competitive reactions among labeled and unlabeled sets of molecules failed to show any differences in DNA polynucleotide sequences, although large differences among the rapidly labeled RNA molecules isolated from different organs were demonstrable.

Additional References:

1. "Mechanisms of Repression and De-Repression within Interphase Chromatin".

2. "Activation of DNA Transcription within Repressed Chromatin".


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