Presented at the 64th Annual Meeting of the American Association for Cancer Research, Atlantic City, NJ, April 11, 1973, and Published in: Proc. Am. Assoc. Cancer Res. 14: 8 (1973): 

"In-Vivo Macrophage Interaction with Lymphocytes in Hodgkin's Disease".

Marilyn A. Masek, Daniel J. Rhoades, and John H. Frenster
Dept. of Medicine, Stanford University, Stanford, California 94305 


Abstract:

Lymphocytes and macrophages frequently are observed infiltrating Hodgkin's Disease lymph nodes, correlating with a favorable prognosis in this disease (Proc. Am. Assoc. Cancer Res. 12: 43 (1971).

Lymph nodes positive for neoplastic cells from untreated patients with the nodular sclerosis type of Hodgkin's Disease were fixed within 30 seconds after surgical removal and were examined by high-resolution electron microscopy. Lymphocytes or macrophages tightly opposed to neoplastic Reed-Sternberg cells correlated directly with cytotoxicity within such neoplastic cells. Three additional types of macrophage activity were observed:
(1) macrophage phagocytosis of collagen fibrils, with desmosomes shared between participating macrophages;
(2) macrophage endocytosis, especially when adjacent to activated lymphocytes, and
(3) macrophage phagocytosis of lymphocytes in the absence of desmosomes or endocytosis.

These studies indicate that immune lymphocytes in Hodgkin's Disease may be directly attacked by macrophages in-vivo, perhaps after such lymphocytes acquire Hodgkin's tumor antigen on their cell surfaces via specific lymphocyte immune interaction with circulating free tumor antigen. Macrophage phagocytosis of lymphocytes may correlate with the absolute lymphopenia and immunosuppression often observed before therapy of patients with advanced stages of Hodgkin's Disease.


Additional References:

1. Chen JJW, Lin Y-C, Yao P-L, Yuan A, Chen H-Y, Shun C-T, Tsai M-F, Chen C-H, Yang P-C, "Tumor-Associated Macrophages: The Double-Edged Sword in Cancer Progression", Journal of Clinical Oncology, vol. 23, no. 5, pp. 953-964 (February 10, 2005).

2. Archibald RB, and Frenster JH, "Quantitative Ultrastructural Analysis of In-Vivo Lymphocyte - Reed-Sternberg Cell Interactions in Hodgkin's Disease", Natl. Cancer Inst. Monogr. 36: 239-245 (1973).

3. Masek MA, Rhoades DJ, and Frenster JH, "In-Vivo Macrophage Interactions with Lymphocytes in Hodgkin's Disease", Proc. Am. Assoc. Cancer Res. 14: 8 (1973).

4. Rowan RA, Masek MA, Thompson JM, and Frenster JH, "Electron Microscopic Localization of Acid Phosphatase Activity within Hodgkin's Disease Lymph Nodes", Proc. Am. Assoc. Cancer Res. 16: 10 (1975).

5. Frenster JH, "Phytohemagglutinin-Activated Autochthonous Lymphocytes for Systemic Immunotherapy of Human Neoplasms".

6. Frenster JH, Papalian MM, Masek MA, and Frenster JA, "Electron Microscopic Analysis of Lymph Node Cellular Activity in Hodgkin's Disease".


 

Journal of Clinical Oncology, vol. 23, no. 5, pp. 953-964 (February 10, 2005):
http://www.jco.org/cgi/content/abstract/23/5/953


"Tumor-Associated Macrophages: The Double-Edged Sword in Cancer Progression".

Chen JJW, Lin Y-C, Yao P-L, Yuan A, Chen H-Y, Shun C-T, Tsai M-F, Chen C-H, Yang P-C,

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