Published in: Proc. Natl. Acad. Sci. USA vol. 72, no. 2, pp. 642-645 (February, 1975):

"Induction by RNA of Inosital Independence in Neurospora crassa."

N. C. Mishra 1, M. C. Niu 2, and E. L. Tatum 1

1 The Rockefeller University, New York N.Y. 10021; and
2 Department of Biology, Temple University, Philadelphia, Pa . 19122


Abstract:

The effect of purified wild-type RNA (allo-RNA) on genetic reversion of inositol-requiring mutant 89601 of Neurospora crassa is described. The mutant ( inos- ) strain, on treatment with the wild-type RNA preparation, was found to revert to wild type ( inos+ ) in significant numbers. RNA from the mutant ( iso-RNA) and allo-RNA digested by RNase were ineffective in causing genetic reversion at the inositol locus. The allo-RNA-induced revertants were stable and showed a Medelian transmission of the inos+ character.


Additional References:

1. Niu MC, and Segal SJ, eds., "The Role of RNA in Reproduction and Development", North-Holland Publ. Co., Amsterdam, 1973.

2. Frenster JH, "Selective Gene De-Repression by De-Repressor RNA", in "Eukaryotic Gene Regulation", Kolodny GM, ed., CRC Press, Inc., Boca Raton, Florida, 1980, pp. 131-143.

3. Frenster JH, "Activation of DNA Transcription within Repressed Chromatin by Nuclear RNA Species", RNA 2001, Sixth Annual Meeting of the RNA Society, 237 (2001).


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