Westman EC, Yancy WS, Edman JS, Tomlin KF, and Perkins CE.

Division of General Internal Medicine, Duke University, 2200 West Main Street, Durham, NC 27705, USA.

E-mail:    ewestman@duke.edu

To determine the effect of a 6-month very low carbohydrate diet program on body weight and other metabolic parameters. Fifty-one overweight or obese healthy volunteers who wanted to lose weight were placed on a very low carbohydrate diet (<25 g/d), with no limit on caloric intake. They also received nutritional supplementation and recommendations about exercise, and attended group meetings at a research clinic. The outcomes were body weight, body mass index, percentage of body fat (estimated by
skinfold thickness), serum chemistry and lipid values, 24-hour urine measurements, and subjective adverse effects. Forty-one (80%) of the 51 subjects attended visits through 6 months. In these subjects, the mean (+/- SD) body weight decreased 10.3% +/- 5.9% (P <0.001) from baseline to 6 months (body weight reduction of 9.0 +/- 5.3 kg and body mass index reduction of 3.2 +/- 1.9 kg/m ². The mean percentage of body weight that was fat decreased 2.9% +/- 3.2% from baseline to 6 months (P <0.001). The mean serum bicarbonate level decreased 2 +/- 2.4 mmol/L (P <0.001) and blood urea nitrogen level increased 2 +/- 4 mg/dL (P <0.001). Serum total cholesterol level decreased 11 +/- 26 mg/dL (P = 0.006), low-density lipoprotein cholesterol level decreased 10 +/- 25 mg/dL (P = 0.01), triglyceride level decreased 56 +/- 45 mg/dL (P <0.001), high-density lipoprotein (HDL) cholesterol level increased 10 +/- 8 mg/dL (P <0.001), and the cholesterol/HDL cholesterol ratio decreased 0.9 +/- 0.6 units (P <0.001). There were no serious adverse effects, but the possibility of adverse effects in the 10 subjects who did not adhere to the program cannot be eliminated. A very low carbohydrate diet program led to sustained weight loss during a 6-month period. Further controlled research is warranted. Publication Types: Clinical Trial
PMID: 12106620 [PubMed - indexed for MEDLINE] 

1. American Association of Clinical Endocrinologists Conference on Insulin Resistance Syndrome (Press Report) August 27, 2002.

2. American Association of Clinical Endocrinologists Conference on Insulin Resistance Syndrome (Findings and Recommendations), August 25-26,  2002.

3. Medical Systems Analysis in Health and Disease.

4. Jackson WPU, and Woolf N, "The Natural History of Pre-Diabetes", New Eng. J. Med. 255: 1183 (1956).

5. Conn JW, and Fajans SS, "The Prediabetic State: A Concept of Resistance to a Genetic Diabetogenic Influence", American Journal of Medicine 31, 839-850 (December, 1961).

6. Ellenberg M, "Clinical Concept of Prediabetes", New York State Journal of Medicine 64, 2885-2891 (December 1, 1964).