Stanford University School of Medicine, 1972.

Student and House Staff Seminars.

Medicine 275. Each quarter, Thursdays, 5 PM, Room M-216.

System Analysis of Latent Disease. A seminar series analyzing the concepts, methods and results which permit the early detection of disease in asymptomatic patients.

1. Latent Disease.

a. The health-disease continuum.
b. The virtues of early diagnosis.

2. Analysis of Flow through Human Systems.

a. Arrival, transformation, and departure of substrate units.
b. Accumulations and deficiencies of substrate flow.
c. The determinants of flow through human systems.

3. The Recognition of Overt Failure.

a. Clinical correlation with flow kinetics.
b. Criteria of effective flow (waiting line length, output rate).
c. Saturation, congestion, and compensation.

4. The Varieties of System Compensation.

a. The turnover of system capacity.
b. Acceleration, activation, and hypertrophy of system capacity.
c. The initiation of compensation.
d. The non-linearity of the compensation response.

5. The Paradox of High-Output Failure.

a. Compensation and system efficiency.
b. Normal and pathologic limits to compensation.

6. The Measurement of Reserve Capacity.

a. Load-tolerance and tolerance tests.
b. Output-potential and sensitivity tests.

7. The Recognition of Latent Failure.

a. The clinical measurement of load-tolerance.
b. The clinical measurement of output-potential.

8. The Therapy of Latent Disease.

a. The question of motivation.
b. Reductions of inflow load.
c. Reductions of resistance to outflow.
d. Increases of system capacity.

REFERENCES:

1. "Limits to Functional Hypertrophy in High-Output Failure", Annals of Internal Medicine 53, 647 (1960).

2. "Load Tolerance as a Quantitative Measure of Health", Annals of Internal Medicine 57, 788 (1962).

3. "Analysis of Queueing and Renewal within Human Systems", Nature 207, 1139 (1965).

If interested, please contact Dr. Frenster , Room M-011, Ext. 5878.